ALDH1
Aldehyde dehydrogenase 1 (ALDH1) comprises several isoforms, including ALDH1A1, ALDH1A2, and ALDH1A3, and functions as an NAD(P)+-dependent enzyme family that oxidizes aldehydes and contributes to cellular detoxification, stem cell maintenance, and differentiation programs[1]. Mechanistically, ALDH1 isoforms participate in the synthesis of all-trans retinoic acid (RA) from retinaldehyde, linking ALDH1 activity to retinoid signaling pathways that regulate self-renewal, differentiation, and cellular homeostasis[1][2]. In disease settings, elevated ALDH1 activity is widely associated with cancer stem cells (CSCs) and correlates with tumor initiation, therapeutic resistance, stemness maintenance, and disease progression across multiple solid tumors[1][2]. ALDH1A1 in particular contributes to resistance against oxidative and aldehyde-induced stress and is frequently enriched in drug-resistant cancer cell populations, making it a valuable experimental marker for CSC identification and functional studies[2][3][4]. Compared with related isoforms, ALDH1A1 and ALDH1A3 both regulate aldehyde detoxification and retinoic acid biosynthesis, yet ALDH1A1 is less efficient at generating all-trans retinoic acid than ALDH1A3 and exhibits distinct regulatory interactions with oncogenic pathways[2][5]. For experimental applications, genetic silencing, pharmacological inhibition, and ALDH-targeting strategies are widely used to investigate CSC biology, overcome chemoresistance, and evaluate isoform-specific therapeutic vulnerabilities in cancer models[3][6][7].
References:
- [1]. Poturnajova M, et al. Aldehyde dehydrogenase 1A1 and 1A3 isoforms - mechanism of activation and regulation in cancer. Cell Signal. 2021;87:110120. [Content Brief]
- [2]. Zanoni M, et al. Emerging Roles of Aldehyde Dehydrogenase Isoforms in Anti-cancer Therapy Resistance. Front Med (Lausanne). 2022;9:795762. [Content Brief]
- [3]. Nguyen AL, et al. The Significance of Aldehyde Dehydrogenase 1 in Cancers. Int J Mol Sci. 2024;26(1):251. [Content Brief]
- [4]. Marcato P, et al. Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform. Cell Cycle. 2011;10(9):1378-1384. [Content Brief]
All Product Categories
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ALDH1 Related Products (23)
Related Products (23)
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Antibodies (3)
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NCT-501 hydrochloride
0 ImagesCat. No.: HY-18768ACAS No.: 2080306-22-3NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
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CM-39
0 ImagesCat. No.: HY-129314CAS No.: 361156-54-9CM-39 is a non-covalent and reversible inhibitor for aldehyde dehydrogenase 1A (ALDH1A) with an IC50 of 0.9 μM.
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PKM2-IN-7
0 ImagesCat. No.: HY-169883CAS No.: 1011641-78-3PKM2-IN-7 (compound 34) can inhibit the interaction between PKM2 and ALDH1A3 without showing significant toxicity to normal cells. PKM2-IN-7 can be used for research in the field of tumors.
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